New Testing Kits For Lung Cancer

Diagnostic Biosystems (DBS), a specialty Immunohistochemistry company, announces its debut as an automated IHC company, introducing the Mosaic 360™ System with a product offering of novel Multiplex Immunohistochemistry kits and a complementary line of optimized IHC reagents.

Built on a history of developing distinctive chromogens to differentiate morphology on a single slide, Diagnostic BioSystems introduces a portfolio of five Mosaic Multiplex™ Lung Cancer Kits for use in tissue analysis of suspected Lung Cancer patients. Pathologists are challenged with scarce tissue availability in patients with cancer. DBS is addressing the tissue challenge with the Mosaic Multiplex ™ kits enabling testing of multiple analytes on one slide with a complete kit optimized for the DBS Mosaic 360™ System automated platform for lab to lab standardized results. 

The Mosaic System™ also includes a new line of “plug and play” reagents optimized on the Mosaic 360™ platform to provide convenience for the Histology Technologist in the Pathology laboratory.

“Diagnostic Biosystems is focused on developing clinically relevant tools for pathologists. We believe it is important to provide the most information with the limited tissue available in cancer patients today. Our standardized Mosaic Multiplex™ lung cancer kits” are focused on solving this problem,” said Dr. Bipin Gupta, PhD, President & CEO of Diagnostic BioSystems. 

During the USCAP, Diagnostic BioSystems will sponsor a Pathologist Roundtable event on Tuesday, March 20, 2012 in Vancouver BC to discuss advances in the use of Multiplex Kits in the analysis of suspected cancers. Two industry experts, Dr. Omar Hameed from Vanderbilt and Dr. Arundhati Rao from Scott & White Healthcare System, will join Marc Key Ph.D., DBS Scientific Advisor, in leading these discussions. 

http://www.businesswire.com/news/calgaryherald/20120319005615/en/Diagnostic-BioSystems-Launches-Automated-IHC-Multiplex-Platform

Pathwork Tissue Origin Test Helps Prolongs Life Of Lung Cancer Patients

The Pathwork Tissue of Origin Test is the only FDA-cleared, Medicare-covered molecular diagnostic for identifying tissue of origin. It uses a tumor’s own genomic information to help pathologists and oncologists diagnose challenging cancer cases such as those that are metastatic or that have a complex clinical history.
“The Tissue of Origin Test significantly altered clinical practice patterns for treating metastatic cancer,” explained John Hornberger, M.D., M.S., CEO/President of Cedar Associates LLC and Principal Investigator of the study. “We saw an increase in overall survival and quality-adjusted life years, resulting in an expected cost per QALY of less than $50,000 per patient, which is within the generally accepted threshold of <$100,000 for cost-effectiveness in the United States.”^1,2

The Pathwork Tissue of Origin Test, available through the Pathwork Diagnostics Laboratory, measures gene expression levels of 2,000 genes and uses proprietary algorithms to compare the tumor’s gene expression pattern to that of 15 tumor types, representing 58 morphologies and 90% of all solid tumors. The test provides objective genomic information to help the physician diagnose what type of cancer the patient has. An accurate diagnosis allows oncologists to match therapy to the cancer.
The Pathwork Tissue of Origin Test has been extensively evaluated in multiple independent studies involving more than 1,100 patient specimens, including large validation studies published in the Journal of Clinical Oncology and the Journal of Molecular Diagnostics.
A retrospective study of 111 cases from 66 academic and community oncology practices illustrates the use of the test in management of cancer patients. Over two thirds of the cases reviewed showed cancer management changed after the Pathwork Tissue of Origin Test result was received. The majority of the oncologists identified the Tissue of Origin Test results as influencing the decision to make a change in therapy.

For more information:  
http://www.genengnews.com/industry-updates/pathwork-tissue-of-origin-test-cost-effective-for-increasing-cancer-patient-survival/139175622/

Advancing Histology To Determine Cancer Diagnosis Video

Histology is extremely important in the diagnosis of all cancers.  Tissues from biopsies procedures from any part of the body are processed in the histology department. After the tissues are processed the pathologist will view the prepared tissue on slides to determine if cancer is present.

Peter Kilner demonstrates a whole new way of approaching tissue processing with the Thermo Scientific Securesette cassette making it easier and more efficient to carry out biopsies and other tests in the histology lab. http://www.thermoscientific.com/pathology